Statistics for Toxicologists / STATISTICAL ANALYSIS FOR BIOLOGY

Katsumi KOBAYASHI, PhDs
5-2, Ooizumi-cho, Iwata city, Shizuoka-ken 438-0044 Japan
E-mail: student-kobayashi@beige.plala.or.jp
UpdateF2012-6-30


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  1. 1-2 The mg/kg/day is converted NOEL of the ppm display, translate from ppm to mg/kg/day (doc)
  2. 1-3. Determination of dose dependence in repeated dose toxicity studies when mid-dose alone is insignificant (doc),

2DFirst auther papers

  1. 2-1. Enomoto, M., Kobayashi, K. and Inoue, H. (1990): Significance of naturally-occurring tumors in evaluating the carcinogenicity of a test compound: A review and an improved carcinogenicity bioassay or chemicals, Journal of Toxicologic Pathology, 3, 1-17.
  2. 2-15. Kobayashi, K. and Inoue, H. (1994): Statistical analytical methods for comparing the incidence of tumors to the historical control data, Journal of Toxicological Science, 19, 1\6.
  3. 2-15. Kobayashi, K., Watanabe, K. and Inoue, H. (1995): Questioning the usefulness of the non-parametric analysis of quantitative data by transformation into ranked data in toxicity studies, The Journal of Toxicological Sciences, 20, 47\53.Opinion of Dr. Finney of this thesis as the letter to editor.
  4. 2-20. Enomoto, M., Inoue, H., Yamamoto, T., Kobayashi, K., Hirouchi, Y., Iwata, H., Yamakawa, S., Kobayashi, K. and Sugiyama, S. (1996): interpretation of bioassay results--- Species, sex, and tumor-site specific carcinogenic effects in long-term studies in rats and mice---, J Toxicol Pathol, 9, 1\12.
  5. 2-21. Kobayashi, K. (1997): A comparison of one- and two-sided tests for judging significant differences in quantitative data obtained in toxicological bioassay of laboratory animals, Journal of Occupational Health, 39, 29\35.
  6. 2-28.Kobayashi, K., Kitajima, S., Miura, D., Inoue, H., Ohori, K., Takeuchi, H. and Takasaki, K. (1999): Characteristics of Quantitative Data Obtained in Toxicity Rodents ---The necessity of Bartlett's test for homogeneity of variance to introduce a rank test---, The Journal of Environmental Biology, 20, (1), 37\48.
  7. 2-29. Kakamu, K., Miura, D., Kitajima, S., Kobayashi, K., Takeuchi, T., Kanamori, M and Takasaki, K. (1999): Comparison Studies on the Effects of Administration by Feeding and Gavage, on Survival rate, Accidental Death Rate and Final Body Weight, Surveyed in Carcinogenicity Studies of NTP, U.S.A. The Journal of Environmental Biology, 20, (2), 163\165D
  8. 2-30. Kobayashi, K., Hagiwara, T., Miura, D., Ohori, K., Takeuchi, H., Kanamori, M. and Takasaki, K. (1999): A Comparison of Spontaneous Malignant Tumors in Humans, Rats, Mice and Dogs, The Journal of Environmental Biology, 20, (3), 189\193.
  9. 2-35.Kobayashi, K. (2001): Trends of the decision tree for selecting hypothesis-testing procedures for the quantitative data obtained in the toxicological bioassay of the rodents in Japan, The Journal of Environmental Biology, 21, (1), 1\9.
  10. 2-38. Kobayashi, K. (2004): Evaluation of toxicity dose levels by cluster analysis, Journal of Toxicological Science, 29, No. 2, 125\129.
  11. 2-39. Kobayashi, K. (2005): Analysis of quantitative data obtained from toxicity studies showing non-normal distribution, Journal of Toxicological Science, 30, No. 2, 127\134.
  12. 2-43. Kobayashi, K., Pillai, K. S., Suzuki, M. and Wang Jie (2008): Do we need to examine the quantitative data obtained from toxicity studies for both normality and homogeneity of variance? The Journal of Environmental Biology, 29, (1). 47\52.
  13. 2-44. Kobayashi, K., Pillai, K. S., Sakuratani, Y., Abe, T., Kamata, E. and Hayashi, M. (2008): Evaluation and assessment of statistical tools used in short-term toxicity studies with small number of rodent, Journal of Toxicological Science, 33, (1), 97\104.
  14. 2-48. Kobayashi, K. (2009): Views inspired from a recent paper: Recommendation on the nonparametric Dunnett test using collaborative work on the evaluation of ovarian toxicity, Journal of Toxicological Science, 34, (3), 355\356. (Letter to the editor).
  15. 2-49. Kobayashi, K., Sakuratani, Y., Abe, T., Nishikawa, S., Yamada, J., Hirose, A., Kamata, E. and Hayashi, M. (2010): Relation between statistics and treatment-related changes obtained from toxicity studies in rats: if detected a significant difference in low or middle dose for quantitative values, this change is considered as incidental change? Journal of Toxicological Science, 35 (1), 79\85. Ref. Various kind of decision tree in Exsus
  16. 2-53. Kobayashi, K., Pillai, K. S., Michael, M., Cherian, K. M. and Ohnishi, M. (2010): Determining NOEL/NOAEL in repeated-dose toxicity studies, when the low dose group shows significant difference in quantitative data, Lab. Anim. Res. 26 (2), 133\137.
  17. 2-54. Kobayashi1, K., Pillai, K. S., Soma Guhatakurta, K.M. Cherian and Mariko Ohnishi (2011): Statistical tools for analysing the data obtained from repeated dose toxicity studies with rodents: A comparison of the statistical tools used in Japan with that of used in other countries, The Journal of Environmental Biology, 32 (1), 11\16.
  18. 2-55. Kobayashi, K., Sakuratani, Y., Abe, T., Yamazaki, K., Nishikawa, S., Yamada, J., Hirose, A.,  Kamata, E. and Hayashi, M. (2011): Influence of coefficient of variation in determining significant difference of quantitative values obtained from 28-day repeated-dose toxicity studies in rats, Journal of Toxicological Science, 36, (1), 63\71.
  19. 2-56. Kobayashi, K. (2011): gLetter to the Editorh Journal of Toxicological Science, 36, (3), 393\394.

5. Books

  1. 5-5. Kobayashi, K. and Pillai, K. S. (2004): Applied Statistics in Toxicology and Pharmacology, Science Publishers, INC. USA.
  2. 5-7. Pillai, K. S and Kobayashi, K. (2012): A Handbook of Applied Statistics in Pharmacology, Science Publishers, INC. USA